In the normal, healthy brain microglia support and keep maintaining neurons. They also help wipe up extra beta amyloid proteins that accumulates in the brain with aging. ‘Microglia will probably be your greatest friend or your most severe enemy based on the indicators they receive,’ Dr. Shytle said. ‘The analogy is usually that you keep talking to them they’ll care for you, but if you stop talking they will get aggressive and have a toxic influence on the brain.’ The USF researchers hypothesize that acetylcholine functions as an endogenous anti-inflammatory substance to help prevent microglia from attacking the brain. This neurotransmitter may regularly signal brain’s disease fighting capability that everything is Okay – – you don’t need to activate more microglia, Dr.‘We have several cases where someone suffered a mind fracture and had been treated with the surgery; in many cases, both unique wound and the trepanation healed.’ It could take many years for the bone to regrow, and in a subset of these, a trepanation hole in the patient's mind might remain for the others of his life, thereby conferring upon him a new ‘survivor’ identity. Related StoriesCharles Bonnet syndrome: an interview with Dr. Dominic ffytcheAddressing standard of living needs in prostate cancers: an interview with Professor Louis DenisLiposomal sizing and the Coulter basic principle: an interview with Professor Melvin E. Klegerman When a patient didn't survive, his skull might have been donated to technology, so to speak, and used for education reasons.