More than 700,000 individuals have been treated with Remicade world-wide for UC in adults, IBD, arthritis rheumatoid, ankylosing spondylitis and psoriatic arthritis. Remicade, known as infliximab generically, belongs to a course of drugs that suppress tumor necrosis factor-alpha, a proteins involved in inflammation. It has been found that Remicade and additional TNF blockers, may raise the risk of lymphoma or additional cancers, and is not recommended for those who have heart failure.Cellular spelunking The top of fat cells contains many small pockets called caveolae . Although their role is not very clear, Paul F. Pilch and colleagues review in the October issue of the Journal of Lipid Research current understanding of caveolae and conclude that one of their major features is to regulate the movement and production of fats in extra fat cells. Caveolae also may help the hormone insulin bind to fat cells, but this is controversial. Insulin binds to proteins receptors on the top of a excess fat cell, which activates proteins inside the cell that help lower the quantity of sugar in the blood and store fats. Some scientists show that insulin receptors put on caveolae, hinting at a possible function of caveolae in insulin function, but other researchers have disputed this locating.