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Autophagy may be the only method to eliminate damaged elements of the cell without trashing the whole lot. Therefore in a nerve cell, for instance, you’d wish autophagy to correct complications without destroying the cell. High degrees of autophagic vesicles have already been noted in some types of degenerative muscle tissue disease also, and in degenerative anxious system illnesses like Huntington’s, Parkinson’s, Alzheimer’s and ALS, . But it isn’t apparent why the vesicles are accumulating. They might be accumulating because they aren’t used, or it could be that the distressed cells are producing even more vesicles.